publications

Abdus-Saboor Lab

Preprints

Schwark R, Ogundare S Weinreb C, Sheng P, Foster W, Toussaint A, Chang P, Tsai W, Comfere M, Arnold A, Guadagnino A, McCloskey D, Schaffer E, Rajan K, Datta SR, Abdus-Saboor I. Behavioral fingerprinting of the naked mole-rat uncovers signatures of eusociality and social touch. bioRxiv (2024)

Upadhyay A, Gradwell M, Vajtay T, Conner J, Sayal AA, Azadegan C, Patel KR, Thackray JK, Bohic M, Imai F, Ogundare S, Yoshida Y, Abdus-Saboor I, Azim E, Abraira V. The dorsal column nuclei scales mechanical allodynia during neuropathic pain. bioRxiv (2024)

Liu D, Rahman M, Johnson A, Tsutsui-Kimura I, Pena N, Talay M, Logeman BL, Finkbeiner S, Choi S, Capo-Battaglia A, Abdus-Saboor I, Ginty DD, Uchida N, Watabe-Uchida M, Dulac C. A hypothalamic circuit underlying the dynamic control of social homeostasis. bioRxiv (2023)

Schaffler M, Johnson M, Hing B, Kahler P, Hultman I, Srivastava S, Arnold J, Blendy J, Hultman R, Abdus-Saboor, I. A critical role for touch neurons in a skin-brain pathway for stress resilience. bioRxiv (2022)

Peer-reviewed research articles:

Burdge J, Ogundare S, Jhumka A, Baer N, Fulton S, Bistis B, Foster W, Toussaint A, Li M, Morizawa Y, Yadessa L, Khan A, Khan A, Delinois A, Mayiseni W, Loran N, Yang G, Abdus-Saboor, I. Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice. eLife (2024). doi.org/10.7554/eLife.99614.1

Inclan-Rico JM, Napuri C, Lin C, Hung LY, Ferguson A, Wu Q, Pastore CF, Stephenson A, Femoe U, Rossi HL, Reed D, Abdus-Saboor I, Luo W, Herbert DR. MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33. Nature Immunology (2024). doi.org/10.1038/s41590-024-01982-y

Sgourdou P, Schaffler M, Choi K, McCall N, Burdge J, Williams J, Corder G, Fuccillo M, Abdus-Saboor I, Epstein D. Impaired pain in mice lacking first order posterior medial thalamic neurons. Pain (2024). PMID: 39190341

Elias L, Succi I, Schaffler M, Foster W, Gradwell M, Bohic M, Fushiki A, Upadhyay A, Ejoh L, Schwark R, Frazer R, Bistis B, Burke J, Saltz V, Boyce J, Jhumka A, Costa R, Abraira V, Abdus-Saboor I. Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity. Cell 186, 577–590 (2023).

“How sexual touch triggers pleasant sensations in mice.” Nature 614, 10.
“The power of social touch: How a loving caress really can ease anxiety.” Washington Post.
“Socio-sexual touch: On the hunt for pleasure signal in the mouse brain.” Current Biology.

Bohic M, Pattison L, Jhumka A, Rossi H, Thackray J, Ricci M, Foster W, Ogundare S, Twomey C, Hilton H, Arnold J, Mossazghi N, Yttri E, Tischfield, MA, Smith ESJ, Abdus-Saboor I.*, Abraira V*. Mapping the neuroethological signatures of pain, analgesia, and recovery in mice. Neuron 111(18):2811-2830 (2023) (*joint senior authors)

Bashkirova EV, Klimpert N, Monahan K, Campbell CE, Osinski J, Tan L, Schieren I, Pourmorady A, Stecky B, Barnea G, Xie XS, Abdus-Saboor I, Shykind BM, Marlin BJ, Gronostajski RM, Fleischmann A, Lomvardas S. Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice. eLife 12:RP87445 (2023)

Toussaint A, Foster W, Jones JM, Kaufmann S, Wachira M, Hughes R, Bongiovanni AR, Famularo ST, Dunham B, Schwark R, Karbalaei R, Dressler C, Bavley CC, Fried NT, Wimmer M, Abdus-Saboor I. Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny. Science Advances eabk2425 (2022).

Jones J, Foster W, Twomey C, Burdge J, Ahmed O, Pereira T. Wojick J, Corder G, Plotkin J, Abdus-Saboor I. A machine-vision approach for automated pain measurement at millisecond timescales. eLife 9:e57258 (2020).

Rossi HL, See LP, Foster W, Pitake S, Gibbs J, Schmidt B, Mitchell CH, Abdus-Saboor I. Evoked and spontaneous pain assessment in a dental pulp injury model. Scientific Reports 17;10(1):2759 (2020).

Reviews & Commentaries:

Zavitsanou A, Abdus-Saboor I. Sex organs sense vibrations through specialized touch neurons. Nature 630(8018):822-823 (2024).

Anissa Jhumka, Abdus-Saboor I. Next generation behavioral sequencing for advancing pain quantification. Curr Opin in Neurobiol. 76:102598 (2022).

Burdge J, Jhumka ZA, Bravo I, Abdus-Saboor I. Taking a deep breath: How a brainstem pathway integrates pain and breathing. Neuron 2;110(5):739-741 (2022).

Elias LJ, Abdus-Saboor I. Bridging skin, brain, and behavior to understand pleasurable social touch. Curr Opin in Neurobiol. 73:102527 (2022).

Fried NT, Chamessian A, Zylka MJ, Abdus-Saboor I. Improving pain assessment in mice and rats with advanced videography and computational approaches. Pain 161(7):1420-1424 (2020).

Schaffler M, Elias L, Abdus-Saboor I. Mechanisms of tactile sensory phenotypes in autism: current understanding, and future directions for research. Curr Psychiatry Rep. 5;21(12):134 (2019).

Ishmail’s postdoc work

Abdus-Saboor I., Fried N.T., Lay M., Burdge J., Swanson K., Fischer R., Jones J., Dong P., Cai W., Guo X., Tao Y.X., Bethea J., Ma M., Dong X., Ding L., Luo W. Development of a mouse pain scale using sub-second behavioral mapping and statistical modeling. Cell Reports 6;28(6):1623-1634 (2019).

Olson W., Abdus-Saboor I., Cui L., Burdge J., Raabe T., Ma M., Luo W. Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors. eLife 12;6:e29507 (2017).

Cui L., Miao X., Liang L., Abdus-Saboor I., Olson W., Fleming M.S., Ma M., Tao Y.X., Luo W. Identification of early RET+ deep dorsal spinal cord interneurons in gating pain. Neuron 91, 1-17 (2016).

Abdus-Saboor I., Al Nufal M.J., Agha M.V., Ruinart de Brimont M., Fleischmann A., Shykind B.M. An expression refinement process ensures singular odorant receptor gene choice. Current Biology 26, 1083–90 (2016).

Fleischmann A., Abdus-Saboor I., Sayed A., Shykind B. Functional interrogation of an odorant receptor locus reveals multiple axes of transcriptional regulation. PLoS Biology 11 (5):e1001568 (2013).

Ishmail’s doctoral work

Abdus-Saboor I., Stone C.E., Murray J.I., Sundaram M.V. The Nkx5/Hmx homeodomain protein MLS-2 is required for proper tube cell shape in the C.elegans excretory system. Developmental Biology 366, 298–307 (2012).

Abdus-Saboor I., Mancuso V.P., Murray J.I., Palozola K., Norris C., Hall D.H., Howell K., Huang K., Sundaram M.V. Notch and Ras promote sequential steps of excretory tube development in C.elegans. Development 138, 3545–3555(2011).